Background and Aim: Diabetes, as the most common chronic metabolic disease, causes a crisis in the physical, psychological and SPIRITUAL aspects, which increases the use of SPIRITUAL resource as a coping mechanism. SPIRITUAL health is one of the variables that enhance the dimension of SPIRITUALity the physical, psychological and SPIRITUAL aspects. SPIRITUAL health coordinates different aspects of human life and it is necessary to adapt to the disease. This study aimed to investigating the relationship between SPIRITUALity NEEDS and contextual Factors with SPIRITUALity well being in cancer patients. Materials and Methods: This descriptive study is Descriptive-correlation. The participants were 113 patients with cancer diseases (female 65, male 48) from Sari city selected through convenience sampling. The data were collected using the SPIRITUALity Well-Being scale, SPIRITUALity NEEDS scale, Contextual Dimension scale. For data analysis, Stepwise regression analysis and SPSS 21 were used. Findings: There was a significant and positive correlation between scores on the components of SPIRITUAL NEEDS and SPIRITUALity well-being, so that subscales of the SPIRITUAL NEEDS such as "Religious NEEDS" (P<0. 001), "Existentialistic NEEDS” (P<0. 001), "need for Inner peace” (P<0. 001) and "Actively Giving NEEDS” (P<0. 001) had positive correlation with SPIRITUALity well being. And among all components of SPIRITUAL NEEDS, Religious NEEDS, Existentialistic NEEDS, Actively Giving NEEDS had a more predictive power in family flexibility. And also there were a significant correlation between dimension of “ behavioral "(P<0. 001), "Political"(P<0. 001), “ Governmental "(P<0. 001), "public health" (P<0. 001), “ Medical "(P<0. 001), "Employment" (P<0. 001) with SPIRITUALity well-being and among all these factors had the highest degree of variance in SPIRITUALity well-being. Ethical Considerations: All participants signed informed consent form before data collection. Conclusion: It is concluded that SPIRITUAL NEEDS and contextual dimension, as two psychological constructs, can play a significant role in creating SPIRITUALity well-being. Therefore, developing plans and approaches to address the patients' SPIRITUAL-religious NEEDS and environmental factors influencing the disease to promote SPIRITUAL well-being of diabetic patients can be beneficial.